Integrative Cancer Biology Program
The Laboratory of Integrative Cancer Immunology (LICM) is a comprehensive research program at the cellular, molecular, biochemical, and genetic level focused on unravelling the metabolic interplay between host immune cells and developing or advancing cancers. Research in the LICM will address questions relating to the metabolic and biochemical pathways of immune cells and cancers, including their crosstalk at the biochemical level. In addition, work will encompass immunometabolism in the cellular context by addressing the biology of immune cells including dissection of the numerous complex interactions between the host and developing and/or progressing tumors that form unique, intratumoral or systemic niches (whether anatomical, metabolic or immunological) which ultimately determine disease risk, prognosis, and/or response to conventional or immune-therapeutic efficacy.
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The Laboratory will also establish collaborative initiatives with other NCI Laboratories with expertise in immunology, chemical biology, natural products, cancer biology, structural biology and mouse cancer genetics modeling to facilitate the development of small molecule- or biologics-based therapeutic applications targeted at modification of immune cell or cancer cell metabolic function toward diminution of progression or to facilitate therapeutic efficacy. Research GroupsCurrently, the LICM is composed of four research groups:- The ImmunoDynamics Group builds quantitative models of the process of cellular decision making in the immune system.- The HLA Immunogenetics Section investigates the host genetic effects on human disease. The Laboratory of Integrative Cancer Immunology (LICM) is a comprehensive research program at the cellular, molecular, biochemical, and genetic level focused on unravelling the metabolic interplay between host immune cells and developing or advancing cancers. Research in the LICM will address questions relating to the metabolic and biochemical pathways of immune cells and cancers, including their crosstalk at the biochemical level. In addition, work will encompass immunometabolism in the cellular context by addressing the biology of immune cells including dissection of the numerous complex interactions between the host and developing and/or progressing tumors that form unique, intratumoral or systemic niches (whether anatomical, metabolic or immunological) which ultimately determine disease risk, prognosis, and/or response to conventional or immune-therapeutic efficacy. The Laboratory will also establish collaborative initiatives with other NCI Laboratories with expertise in immunology, chemical biology, natural products, cancer biology, structural biology and mouse cancer genetics modeling to facilitate the development of small molecule- or biologics-based therapeutic applications targeted at modification of immune cell or cancer cell metabolic function toward diminution of progression or to facilitate therapeutic efficacy.
Research GroupsCurrently, the LICM is composed of four research groups:- The ImmunoDynamics Group builds quantitative models of the process of cellular decision making in the immune system.- The HLA Immunogenetics Section investigates the host genetic effects on human disease.
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NIH Guide: ORIENTATION MEETING FOR NCI INTEGRATIVE CANCER BIOLOGY PROGRAM RFA (CA-04-013)ORIENTATION MEETING FOR NCI INTEGRATIVE CANCER BIOLOGY PROGRAM RFA (CA-04-013)RELEASE DATE: December 9, 2003NOTICE: NOT-CA-04-005National Cancer Institute (NCI)The Division of Cancer Biology (DCB) of the National Cancer Institute(NCI) announces a planning meeting to discuss the new Request forApplication (RFA) entitled “Integrative Cancer Biology Programs” (ICBP). Thepurpose of the ICBP RFA is to develop a few comprehensive programs inintegrative or systems cancer biology. The goal of this initiative isto promote the analysis of cancer as a complex biological system, withan ultimate goal of developing reliably predictive in silico orcomputational models of cancer initiation and progression and for thedevelopment of cancer interventions. The overall thrust of thisprogram will be the integration of experimental and computationalapproaches towards the understanding of cancer biology. Thisinitiative will encourage the emergence of integrative cancer biologyas a distinct field.This workshop will be co-sponsored by the NCI Center for Bioinformatics(NCICB). Participation in a pre-application ICBP meeting will be opento all parties interested in applying to the RFA.
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The meeting will bean opportunity to clarify questions about the overall program and todiscuss specific concerns about data standards, infrastructure andapproaches to sharing of data and models as related to the ICBP and thecommunities. The workshop is planned as a one-day event to be held ata suitable location near NIH towards the end of January.
The exactdate and location of this workshop will be posted on the DCB website(site listed below). Although attendance at this meeting is notrequired for the successful submission of an RFA application,investigators considering submitting an application in response to theRFA are urged to participate.